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When their seminal research was published in *Cell* in March 2017, it introduced the first precision senolytic peptide capable of selectively eliminating senescent cells while sparing healthy tissue, opening unprecedented opportunities for studying aging mechanisms and developing research tools for age-related cellular dysfunction

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In a mouse model of lung inflammation, treatment with compound 33 significantly reduced TNF-, IL-6, IL-17, and NF-B-positive cell populations while increasing Foxp3 and IB-positive cell populations in whole blood and pleural fluid (113)

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It also reduces stress by calming excitatory brain signals, supporting recovery from sleep disturbances, alcohol or drug withdrawal, and chronic stress

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